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Article

Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population.

Diabetes research and clinical practice - 1 Sept 2017

Winters Alexandra, Ramos-Molina Bruno, Jarvela Timothy S, Yerges-Armstrong Laura, Pollin Toni I, Lindberg Iris

Abstract excerpt

AIMS: In humans, noncoding variants of PCSK2, the gene encoding prohormone convertase 2 (PC2), have been previously associated with risk for and age of onset of type 2 diabetes (T2D). The aims of this study were to identify coding variants in PCSK2; to determine their possible association with glucose handling; and to determine functional outcomes for coding variants in biochemical studies. METHODS: Exome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28719828
DOI: 10.1016/j.diabres.2017.06.023
PMCID: PMC5572827

Genes

PCSK2
MAF

Variants

rs200711626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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