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Article

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2009

Seike Masahiro, Goto Akiteru, Okano Tetsuya, Bowman Elise D, Schetter Aaron J, Horikawa Izumi, Mathe Ewy A, Jen Jin, Yang Ping, Sugimura Haruhiko, Gemma Akihiko, Kudoh Shoji, Croce Carlo M, Harris Curtis C

Abstract excerpt

Fifteen percent of lung cancer cases occur in never-smokers and show characteristics that are molecularly and clinically distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), ar...

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Identifiers

PMID: 19597153
DOI: 10.1073/pnas.0905234106
PMCID: PMC2715493

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19597153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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