Article
Alterations of p14ARF, p53, and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma.
Cancer research - 15 Jul 2001
Nicholson S A, Okby N T, Khan M A, Welsh J A, McMenamin M G, Travis W D, Jett J R, Tazelaar H D, Trastek V, Pairolero P C, Corn P G, Herman J G, Liotta L A, Caporaso N E, Harris C C
Abstract excerpt
Overexpression of E2F-1 induces apoptosis by both a p14ARF-p53- and a p73-mediated pathway. p14ARF is the alternate tumor suppressor product of the INK4a/ARF locus that is inactivated frequently in lung carcinogenesis. Because p14ARF stabilizes p53, it has been proposed that the loss of p14ARF is functionally equivalent to a p53 mutation. We have tested this hypothesis by examining the genomic status of the...
Topics
- Apoptosis
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- Carrier Proteins
- Cell Cycle Proteins
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor