Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic association studies of adult-onset diseases using the case-spouse and case-offspring designs.

American journal of epidemiology - 1 Dec 2003

Lee Wen-Chung

Abstract excerpt

Genetic studies of complex human diseases rely heavily on the family-based association paradigm. However, recruiting parents or siblings can be a difficult task in practice. The author proposes two alternatives, the case-spouse and the case-offspring designs, that are to be analyzed by the mating disequilibrium test. Two assumptions are required: 1) the marker genotype frequencies at conception should be the same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidemiologic Methods
Share to Genetic Predisposition to Disease
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Parents

Share to Polymorphism, Genetic

Share to Spouses

Source

Identifiers

PMID: 14630596
DOI: 10.1093/aje/kwg266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic association studies of adult-onset diseases using the case-spouse and case-offspring designs.PMID 14630596Read ↗

Assessing effects of disease genes and gene-environment interactions: the case-spouse design and the counterfactual-control analysis.Semantic proximity Read ↗

Design Considerations for Genetic Linkage and Association Studies.Semantic proximity Read ↗

A hybrid design for studying genetic influences on risk of diseases with onset early in life.Semantic proximity Read ↗

Relative risk for genetic associations: the case-parent triad as a variant of case-cohort design.Semantic proximity Read ↗

Case-control studies of genotypic relative risks using children of cases as controls.Semantic proximity Read ↗

Commentary: the affected sib-pair method in the context of an epidemiologic study design.Semantic proximity Read ↗

Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads".Semantic proximity Read ↗

Case-sibling studies that acknowledge unstudied parents and permit the inclusion of unmatched individuals.Semantic proximity Read ↗

Analysis of case-parental control studies: method for the study of associations between disease and genetic markers.Semantic proximity Read ↗

Case-sibling gene-association studies for diseases with variable age at onset.Semantic proximity Read ↗

Appropriate use of information on family history of disease in recruitment for linkage analysis studies.Semantic proximity Read ↗

Assortative mating and within-spouse pair comparisonsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.