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Article

Assessing effects of disease genes and gene-environment interactions: the case-spouse design and the counterfactual-control analysis.

Journal of epidemiology and community health - 1 Aug 2006

Lee Wen-Chung, Chang Chin-Hao

Abstract excerpt

BACKGROUND: Assessing joint genetic and environmental contributions to disease risk is the central issue in many genetic epidemiological studies. To characterise the effects of a gene, the case-control study may suffer from the problem of population stratification bias. For a late onset disease, recruiting control subjects into case-parents and case-sibling studies may be difficult. METHODS: Two novel approaches...

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Identifiers

PMID: 16840757
DOI: 10.1136/jech.2005.043554
PMCID: PMC2588086

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