Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired SDF1/CXCR4 signaling in glial progenitors derived from SOD1(G93A) mice.

Journal of neuroscience research - 15 Aug 2007

Luo Yongquan, Xue Haipeng, Pardo Andrea C, Mattson Mark P, Rao Mahendra S, Maragakis Nicholas J

Abstract excerpt

Mutations in the superoxide dismutase 1 (SOD1) gene are associated with familial amyotrophic lateral sclerosis (ALS), and the SOD1(G93A) transgenic mouse has been widely used as one animal model for studies of this neurodegenerative disorder. Recently, several reports have shown that abnormalitie...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Chemokine CXCL12
Share to Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuroglia

Share to Receptors, CXCR4

Share to Spinal Cord

Share to Stem Cells

Share to Superoxide Dismutase

Source

Identifiers

PMID: 17567884
DOI: 10.1002/jnr.21398

Genes

SOD1
CXCR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17567884-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired SDF1/CXCR4 signaling in glial progenitors derived from SOD1(G93A) mice.PMID 17567884Read ↗

Genetic validation of a therapeutic target in a mouse model of ALS.Semantic proximity Read ↗

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP).Semantic proximity Read ↗

Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic miceSemantic proximity Read ↗

Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.Semantic proximity Read ↗

Mutant Ataxin-1 Inhibits Neural Progenitor Cell Proliferation in SCA1.Semantic proximity Read ↗

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice.Semantic proximity Read ↗

Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons.Semantic proximity Read ↗

Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants.Semantic proximity Read ↗

Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice.Semantic proximity Read ↗

Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression.Semantic proximity Read ↗

Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.