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Article

Mutant Ataxin-1 Inhibits Neural Progenitor Cell Proliferation in SCA1.

Cerebellum (London, England) - 1 Apr 2017

Cvetanovic Marija, Hu Yuan-Shih, Opal Puneet

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by the expansion of a polyglutamine (Q) repeat tract in the protein ataxin-1 (ATXN1). Beginning as a cerebellar ataxic disorder, SCA1 progresses to involve the cerebral cortex, hippocampus, and brainstem. Using SCA1 knock-in mice that mirror the complexity of the human disease, we report a significant decrease in the...

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Identifiers

PMID: 27306906
DOI: 10.1007/s12311-016-0794-9
PMCID: PMC5510931

Genes

ATXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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