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Article

Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.

PloS one - 1 Jan 2011

Lepore Angelo C, O'Donnell John, Kim Andrew S, Williams Timothy, Tuteja Alicia, Rao Mahendra S, Kelley Linda L, Campanelli James T, Maragakis Nicholas J

Abstract excerpt

Cellular abnormalities are not limited to motor neurons in amyotrophic lateral sclerosis (ALS). There are numerous observations of astrocyte dysfunction in both humans with ALS and in SOD1(G93A) rodents, a widely studied ALS model. The present study therapeutically targeted astrocyte replacement in this model via transplantation of human Glial-Restricted Progenitors (hGRPs), lineage-restricted progenitors derived...

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Identifiers

PMID: 21998733
DOI: 10.1371/journal.pone.0025968
PMCID: PMC3187829

Genes

SOD1

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