Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice.

Journal of neuropathology and experimental neurology - 1 Aug 2011

Hossaini Mehdi, Cardona Cano Sebastian, van Dis Vera, Haasdijk Elize D, Hoogenraad Casper C, Holstege Jan C, Jaarsma Dick

Abstract excerpt

Motor neuron degeneration and skeletal muscle denervation are hallmarks of amyotrophic lateral sclerosis (ALS), but other neuron populations and glial cells are also involved in ALS pathogenesis. We examined changes in inhibitory interneurons in spinal cords of the ALS model low-copy Gurney G93A-SOD1 (G1del) mice and found reduced expression of markers of glycinergic and GABAergic neurons, that is, glycine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calbindins
Share to Choline O-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galectin 3

Share to Glutamate Decarboxylase

Share to Interneurons

Share to Parvalbumins

Share to Proto-Oncogene Proteins c-jun

Share to S100 Calcium Binding Protein G

Source

Identifiers

PMID: 21760539
DOI: 10.1097/NEN.0b013e31822581ac

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice.PMID 21760539Read ↗

Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice.Semantic proximity Read ↗

Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A miceSemantic proximity Read ↗

Change in superoxide dismutase 1 protein localization towards mitochondria: an immunohistochemical study in transgenic G93A mice.Semantic proximity Read ↗

Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology.Semantic proximity Read ↗

Imbalanced excitatory to inhibitory synaptic input precedes motor neuron degeneration in an animal model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.Semantic proximity Read ↗

Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.Semantic proximity Read ↗

Accumulation of Misfolded SOD1 in Dorsal Root Ganglion Degenerating Proprioceptive Sensory Neurons of Transgenic Mice with Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Early interneuron dysfunction in ALS: Insights from a mutant sod1 zebrafish modelSemantic proximity Read ↗

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis.Semantic proximity Read ↗

Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidaseSemantic proximity Read ↗

Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.