Article
Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.
PLoS genetics - 1 May 2013
Labrador Leticia, Barroso Consuelo, Lightfoot James, Müller-Reichert Thomas, Flibotte Stephane, Taylor Jon, Moerman Donald G, Villeneuve Anne M, Martinez-Perez Enrique
Abstract excerpt
Pairing of homologous chromosomes during early meiosis is essential to prevent the formation of aneuploid gametes. Chromosome pairing includes a step of homology search followed by the stabilization of homolog interactions by the synaptonemal complex (SC). These events coincide with dramatic changes in nuclear organization and rapid chromosome movements that depend on cytoskeletal motors and are mediated by...
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