Sensitive immunodetection of pseudo-mutant conformation of p53 protein in human cells using immune complex with protein A conjugates.

Abstract excerpt

The p53 tumor suppressor protein is a biologically very important molecule. In addition to its central relevance in cancer, its function as an inducer of cell cycle checkpoint and apoptosis may be important in a number of cellular stress responses. However, studies of p53 interactions with other proteins have been hampered in large part by the low abundance of normal p53 in cells. Moreover, the detection of p53...

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