Article
Primary proliferative T cell response to wild-type p53 protein in patients with breast cancer.
European journal of immunology - 1 Jun 1995
Tilkin A F, Lubin R, Soussi T, Lazar V, Janin N, Mathieu M C, Lefrère I, Carlu C, Roy M, Kayibanda M
Abstract excerpt
Mutations in the p53 tumor suppressor gene are the most frequent genetic alterations found in human tumors. There are mainly point mutations that lead to single amino acid substitutions. The mutated proteins have a longer half-life than wild-type p53 and accumulate in the nucleus of tumor cells. Anti-p53 antibodies have been found in sera of patients with several types of cancers including breast cancer. This...
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