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Article

Sequence-specific interaction of a conformational domain of p53 with DNA.

Cancer research - 15 Nov 1993

Srinivasan R, Roth J A, Maxwell S A

Abstract excerpt

Mutations within a conserved "conformational" domain of the p53 protein have frequently been observed in a wide variety of human cancers. A hybrid protein containing the wild-type conformational domain of p53 fused to protein A bound to calf thymus DNA and a specific p53 DNA-binding motif. Hybrid proteins containing mutations in p53 bound to DNA less efficiently than wild-type hybrid protein. In addition,...

Topics

Animals
Antigens, Polyomavirus Transforming
Base Sequence
Cattle
Conserved Sequence
DNA
Molecular Sequence Data
Mutation
Simian virus 40
Staphylococcal Protein A
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8221671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8221671-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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