Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The proteasome is involved in determining differential utilization of double-strand break repair pathways.

Oncogene - 29 Nov 2007

Gudmundsdottir K, Lord C J, Ashworth A

Abstract excerpt

The DSS1 protein interacts with the breast cancer susceptibility protein BRCA2 that plays an integral role in the repair of DNA double-strand breaks (DSBs). DSS1 has also been shown to interact with components of the 26S proteasome in Saccharomyces cerevisiae and in human tumour cells. This raises the possibility of functional interplay between the DNA repair machinery and the proteasome. We show here that human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to BRCA2 Protein
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Exoribonucleases

Share to Hexosyltransferases

Share to Proteasome Endopeptidase Complex

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 17563742
DOI: 10.1038/sj.onc.1210579

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The proteasome is involved in determining differential utilization of double-strand break repair pathways.PMID 17563742Read ↗

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.Semantic proximity Read ↗

Proteasome involvement in the repair of DNA double-strand breaks.Semantic proximity Read ↗

Depletion of DSS1 protein disables homologous recombinational repair in human cells.Semantic proximity Read ↗

The 26S proteasome negatively regulates the level of overall genomic nucleotide excision repair.Semantic proximity Read ↗

Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.Semantic proximity Read ↗

The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair.Semantic proximity Read ↗

Yeast Rpn4 Links the Proteasome and DNA Repair via RAD52 Regulation.Semantic proximity Read ↗

Proteolysis of a nucleotide excision repair protein by the 26 S proteasome.Semantic proximity Read ↗

USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.Semantic proximity Read ↗

Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.Semantic proximity Read ↗

A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene.Semantic proximity Read ↗

The dominant temperature-sensitive lethal DTS7 of Drosophila melanogaster encodes an altered 20S proteasome beta-type subunit.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.