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Article

USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.

Molecular and cellular biology - 15 Nov 2014

Kim Jihoon, D'Annibale Sara, Magliozzi Roberto, Low Teck Yew, Jansen Petra, Shaltiel Indra A, Mohammed Shabaz, Heck Albert J R, Medema Rene H, Guardavaccaro Daniele

Abstract excerpt

In response to genotoxic stress, DNA damage checkpoints maintain the integrity of the genome by delaying cell cycle progression to allow for DNA repair. Here we show that the degradation of the basic helix-loop-helix (bHLH) transcription factor DEC1, a critical regulator of cell fate and circadian rhythms, controls the DNA damage response. During unperturbed cell cycles, DEC1 is a highly unstable protein that is...

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PMID: 25202122
DOI: 10.1128/MCB.00530-14
PMCID: PMC4248718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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