Article
The dominant temperature-sensitive lethal DTS7 of Drosophila melanogaster encodes an altered 20S proteasome beta-type subunit.
Genetics - 1 Jan 1999
Smyth K A, Belote J M
Abstract excerpt
Proteasomes are multicatalytic complexes that function as the major proteolytic machinery in regulated protein degradation. The eukaryotic 20S proteasome proteolytic core structure comprises 14 different subunits: 7 alpha-type and 7 beta-type. DTS7 is a dominant temperature-sensitive (DTS) lethal...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- Cysteine Endopeptidases
- Drosophila melanogaster
- Genes, Insect
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis
- Phenotype
- Proteasome Endopeptidase Complex
- Protein Conformation
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Temperature
- Transgenes