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Article

Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.

PLoS genetics - 19 Feb 2010

Ben-Aroya Shay, Agmon Neta, Yuen Karen, Kwok Teresa, McManus Kirk, Kupiec Martin, Hieter Philip

Abstract excerpt

To expand the known spectrum of genes that maintain genome stability, we screened a recently released collection of temperature sensitive (Ts) yeast mutants for a chromosome instability (CIN) phenotype. Proteasome subunit genes represented a major functional group, and subsequent analysis demonstrated an evolutionarily conserved role in CIN. Analysis of individual proteasome core and lid subunit mutations showed...

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Identifiers

PMID: 20174551
DOI: 10.1371/journal.pgen.1000852
PMCID: PMC2824753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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