Article
The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair.
Molecular cell - 1 Jun 1999
Russell S J, Reed S H, Huang W, Friedberg E C, Johnston S A
Abstract excerpt
The 26S proteasome degrades proteins targeted by the ubiquitin pathway, a function thought to explain its role in cellular processes. The proteasome interacts with the ubiquitin-like N terminus of Rad23, a nucleotide excision repair (NER) protein, in Saccharomyces cerevisiae. Deletion of the ubiquitin-like domain causes UV radiation sensitivity. Here, we show that the ubiquitin-like domain of Rad23 is required...
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