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Article

Depletion of DSS1 protein disables homologous recombinational repair in human cells.

Mutation research - 10 Dec 2010

Kristensen Colleen N, Bystol Karin M, Li Boran, Serrano Lourdes, Brenneman Mark A

Abstract excerpt

DSS1 is a small, highly acidic protein widely conserved among eukaryotes as a component of the 19S proteasome and implicated in ubiquitin-mediated proteolysis. The BRCA2 tumor suppressor protein functions in homologous recombinational repair (HRR) of DNA double-strand breaks, and does so in part through the actions of a carboxy-proximal region that binds DNA and several other proteins, including DSS1. In the...

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Topics

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Share to BRCA2 Protein
Share to Cell Line, Tumor
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Gene Silencing

Share to Proteasome Endopeptidase Complex

Share to Recombination, Genetic

Share to RNA Interference

Source

Identifiers

PMID: 20817001
DOI: 10.1016/j.mrfmmm.2010.08.007

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Depletion of DSS1 protein disables homologous recombinational repair in human cells.PMID 20817001Read ↗

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