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Article

Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.

The EMBO journal - 19 May 2010

Zhang Liyong, Park Chi-Hoon, Wu Jing, Kim Hyun, Liu Weijun, Fujita Takeo, Balasubramani Manimalha, Schreiber Emanuel M, Wang Xiao-Fan, Wan Yong

Abstract excerpt

Recent studies have shown a critical function for the ubiquitin-proteasome system (UPS) in regulating the signalling network for DNA damage responses and DNA repair. To search for new UPS targets in the DNA damage signalling pathway, we have carried out a non-biased assay to identify fast-turnove...

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Source

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Identifiers

PMID: 20424596
DOI: 10.1038/emboj.2010.55
PMCID: PMC2876963

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20424596-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.PMID 20424596Read ↗

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ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesSemantic proximity Read ↗

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Replication-dependent and -independent Responses of RAD18 to DNA Damage in Human CellsSemantic proximity Read ↗

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