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Article

Proteasome involvement in the repair of DNA double-strand breaks.

Molecular cell - 22 Dec 2004

Krogan Nevan J, Lam Mandy H Y, Fillingham Jeffrey, Keogh Michael-Christopher, Gebbia Marinella, Li Joyce, Datta Nira, Cagney Gerard, Buratowski Stephen, Emili Andrew, Greenblatt Jack F

Abstract excerpt

Affinity purification of the yeast 19S proteasome revealed the presence of Sem1 as a subunit. Its human homolog, DSS1, was found likewise to copurify with the human 19S proteasome. DSS1 is known to associate with the tumor suppressor protein BRCA2 involved in repair of DNA double-strand breaks (DSBs). We demonstrate that Sem1 is required for efficient repair of an HO-generated yeast DSB using both homologous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15610744
DOI: 10.1016/j.molcel.2004.11.033

Genes

BRCA2
SEM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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