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Article

Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region.

Molecular and cellular biology - 1 Aug 2007

Huang Feng-Ting, Yu Kefei, Balter Barbara B, Selsing Erik, Oruc Zeliha, Khamlichi Ahmed Amine, Hsieh Chih-Lin, Lieber Michael R

Abstract excerpt

The mechanism by which the cytidine deaminase activation-induced deaminase (AID) acts at immunoglobulin heavy-chain class switch regions during mammalian class switch recombination (CSR) remains unclear. R-loops have been proposed as a basis for this targeting. Here, we show that the difference between various forms of the Smu locus that can or cannot undergo CSR correlates well with the locations and...

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Share to B-Lymphocytes
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin mu-Chains

Share to Immunoglobulin Switch Region

Share to Lymphocyte Activation

Share to Recombination, Genetic

Share to Ribonuclease H

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Source

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Identifiers

PMID: 17562862
DOI: 10.1128/MCB.00702-07
PMCID: PMC1952116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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