Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cells.

Journal of neurochemistry - 1 Sept 1999

Sebök A, Nusser N, Debreceni B, Guo Z, Santos M F, Szeberenyi J, Tigyi G

Abstract excerpt

The goal of the present study was to characterize the effects of RhoA at different stages of nerve growth factor (NGF)-induced neuronal differentiation in the PC12 model. This comparative analysis was prompted by previous studies that reported apparently opposite effects for Rho in different models of neuronal differentiation and regeneration. PC12 cells were transfected with activated V14RhoA or dominant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Nerve Growth Factors

Share to Nerve Regeneration

Share to Neurites

Share to PC12 Cells

Source

Identifiers

PMID: 10461884
DOI: 10.1046/j.1471-4159.1999.0730949.x

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cells.PMID 10461884Read ↗

Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons.Semantic proximity Read ↗

Rac is required for growth cone function but not neurite assembly.Semantic proximity Read ↗

Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.Semantic proximity Read ↗

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.Semantic proximity Read ↗

The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells.Semantic proximity Read ↗

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.Semantic proximity Read ↗

Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.Semantic proximity Read ↗

Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system.Semantic proximity Read ↗

Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones.Semantic proximity Read ↗

The novel GTPase Rit differentially regulates axonal and dendritic growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.