Article
Multiple Gi proteins participate in nerve growth factor-induced activation of c-Jun N-terminal kinases in PC12 cells.
Neurochemical research - 1 Jun 2009
Tso Prudence H, Morris Christina J, Yung Lisa Y, Ip Nancy Y, Wong Yung H
Abstract excerpt
Nerve growth factor (NGF)-mediated activation of mitogen-activated protein kinases (MAPK) is critical for differentiation and apoptosis of PC12 cells. Since NGF employs stress-activated c-Jun N-terminal kinase (JNK) to regulate both programmed cell death and neurite outgrowth of PC12 cells, we examined NGF-regulated JNK activity and the role of G(i/o) proteins. Induction of JNK phosphorylation by NGF occurred in...
Topics
- Animals
- Cells, Cultured
- Embryo, Mammalian
- Enzyme Activation
- GTP-Binding Protein alpha Subunits, Gi-Go
- JNK Mitogen-Activated Protein Kinases
- Janus Kinase 3
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3
- Mutation
- Nerve Growth Factor
- Neurons