Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression.

Biochemical pharmacology - 1 Aug 2007

Matsuoka Hideaki, Fujimura Takao, Hayashi Masako, Matsuda Kaori, Ishii Yoshinori, Aramori Ichiro, Mutoh Seitaro

Abstract excerpt

Previous studies have shown that HDAC inhibitors selectively inhibit IL-2 gene expression, but the mechanism of this inhibition remains to be elucidated. It was recently reported that HDAC4, a component of the nuclear hormone receptor corepressor (N-CoR) complex, associates with the IL-2 promoter via the transcription factor myocyte enhancer factor 2 (MEF2). We therefore focused on the role of HDAC4/N-CoR complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Inhibitors
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Interleukin-2

Share to Peptides, Cyclic

Share to Repressor Proteins

Share to RNA, Small Interfering

Source

Identifiers

PMID: 17559812
DOI: 10.1016/j.bcp.2007.05.002

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression.PMID 17559812Read ↗

Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.Semantic proximity Read ↗

Function of Histone Deacetylase Inhibitors in InflammationSemantic proximity Read ↗

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.Semantic proximity Read ↗

Myocyte Enhancer Factor 2 Mediates Calcium-dependent Transcription of the Interleukin-2 Gene in T LymphocytesSemantic proximity Read ↗

Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation.Semantic proximity Read ↗

Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.Semantic proximity Read ↗

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.Semantic proximity Read ↗

Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.Semantic proximity Read ↗

Biological roles and mechanistic actions of co-repressor complexes.Semantic proximity Read ↗

Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.Semantic proximity Read ↗

Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.Semantic proximity Read ↗

SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.