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Article

Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.

Journal of molecular and cellular cardiology - 1 Dec 2006

Nakagawa Yasuaki, Kuwahara Koichiro, Harada Masaki, Takahashi Nobuki, Yasuno Shinji, Adachi Yuichiro, Kawakami Rika, Nakanishi Michio, Tanimoto Keiji, Usami Satoru, Kinoshita Hideyuki, Saito Yoshihiko, Nakao Kazuwa

Abstract excerpt

We recently reported that a transcriptional repressor, neuron-restrictive silencer factor (NRSF), represses expression of fetal cardiac genes, including atrial and brain natriuretic peptide (ANP and BNP), by recruiting class I histone deacetylase (HDAC) and that attenuation of NRSF-mediated repression contributes to the reactivation of fetal gene expression during cardiac hypertrophy. The molecular mechanism by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17011572
DOI: 10.1016/j.yjmcc.2006.08.010

Genes

HDAC4
HDAC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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