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Article

Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.

The Journal of biological chemistry - 13 Aug 2004

Li Xiaofang, Song Song, Liu Yu, Ko Sung-Hwan, Kao Hung-Ying

Abstract excerpt

Class II histone deacetylases (HDACs) play a role in myogenesis and inhibit transcriptional activation by myocyte enhancer factors 2. A distinct feature of class II HDACs is their ability to shuttle between the nucleus and the cytoplasm in a cell type- and signal-dependent manner. We demonstrate here that treatment with the 26 S proteosome inhibitors, MG132 and ALLN, leads to detection of ubiquitinated HDAC7 and...

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Source

Identifiers

PMID: 15166223
DOI: 10.1074/jbc.M405179200

Genes

HDAC7
HDAC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.PMID 15166223Read ↗

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The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphomaSemantic proximity Read ↗

Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression.Semantic proximity Read ↗

The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.Semantic proximity Read ↗

Histone Deacetylase 7 Associates With Runx2 and Represses Its Activity During Osteoblast Maturation in a Deacetylation-Independent MannerSemantic proximity Read ↗

CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression.Semantic proximity Read ↗

HDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription.Semantic proximity Read ↗

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.Semantic proximity Read ↗

Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.Semantic proximity Read ↗

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