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Article

Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation.

Molecular and cellular biology - 1 Jan 2007

Haberland Michael, Arnold Michael A, McAnally John, Phan Dillon, Kim Yuri, Olson Eric N

Abstract excerpt

Skeletal muscle development is controlled by the myocyte enhancer factor (MEF2) and myogenic basic helix-loop-helix (bHLH) families of transcription factors, which associate and synergistically activate muscle gene expression. Muscle differentiation is further reinforced by positive-feedback loops in which myogenic bHLH proteins activate their own expression and the expression of MEF2, while MEF2 stimulates...

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Source

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Identifiers

PMID: 17101791
DOI: 10.1128/MCB.01415-06
PMCID: PMC1800816

Genes

HDAC9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation.PMID 17101791Read ↗

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