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Article

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.

Cell - 29 Dec 2006

Lam Yung C, Bowman Aaron B, Jafar-Nejad Paymaan, Lim Janghoo, Richman Ronald, Fryer John D, Hyun Eric D, Duvick Lisa A, Orr Harry T, Botas Juan, Zoghbi Huda Y

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is one of several neurodegenerative diseases caused by expansion of a polyglutamine tract in the disease protein, in this case, ATAXIN-1 (ATXN1). A key question in the field is whether neurotoxicity is mediated by aberrant, novel interactions with the expanded protein or whether its wild-type functions are augmented to a deleterious degree. We examined soluble protein...

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Source

Identifiers

PMID: 17190598
DOI: 10.1016/j.cell.2006.11.038

Genes

ATXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.PMID 17190598Read ↗

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.Semantic proximity Read ↗

Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological diseaseSemantic proximity Read ↗

Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.Semantic proximity Read ↗

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.Semantic proximity Read ↗

Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1Semantic proximity Read ↗

Identification of genes that modify ataxin-1-induced neurodegeneration.Semantic proximity Read ↗

Ataxin-2: a powerful RNA-binding proteinSemantic proximity Read ↗

Disrupting ATXN1 Nuclear Localization in a Knock-in SCA1 Mouse Model Improves a Spectrum of SCA1-Like Phenotypes and their Brain Region Associated Transcriptomic ProfilesSemantic proximity Read ↗

Aggregation of polyQ‐extended proteins is promoted by interaction with their natural coiled‐coil partnersSemantic proximity Read ↗

ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.Semantic proximity Read ↗

CAPRIN1P512L causes aberrant protein aggregation and associates with early-onset ataxia.Semantic proximity Read ↗

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors.Semantic proximity Read ↗

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