Article
The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1.
Nature - 30 Oct 1997
Matilla A, Koshy B T, Cummings C J, Isobe T, Orr H T, Zoghbi H Y
Abstract excerpt
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder characterized by ataxia, progressive motor deterioration, and loss of cerebellar Purkinje cells. SCA1 belongs to a growing group of neurodegenerative disorders caused by expansion of CAG repeats, which encode glutamine. Although the proteins containing these repeats are widely expressed, the neurodegeneration in SCA1 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.