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Article

A role for both wild-type and expanded ataxin-7 in transcriptional regulation.

Neurobiology of disease - 1 Dec 2005

Ström Anna-Lena, Forsgren Lars, Holmberg Monica

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease primarily affecting the brainstem, retina and Purkinje cells of the cerebellum. The disease is caused by a polyglutamine expansion in ataxin-7, a protein found in two complexes TFTC and STAGA, involved in transcriptional regulation. Transcriptional dysregulation has been implicated in the pathology of several polyglutamine diseases. In this...

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Identifiers

PMID: 15936949
DOI: 10.1016/j.nbd.2005.04.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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