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Article

Nuclear import of aristaless-related homeobox protein via its NLS1 regulates its transcriptional function.

Molecular and cellular biochemistry - 1 Sept 2013

Ye Wenduo, Lin Wenbo, Tartakoff Alan M, Ma Qilin, Tao Tao

Abstract excerpt

Nucleocytoplasmic transport of transcription factors is essential in eukaryotes. We previously reported the presence of two functional NLSs in the homeodomain protein, aristaless-related homeobox (Arx) protein, which is a key transcriptional repressor of LMO1, SHOX2, and PAX4 during development. NLS2, that overlaps the homeodomain, is recognized directly by multiple importin βs, but not by importin αs. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23771350
DOI: 10.1007/s11010-013-1706-7

Genes

LMO1
PAX4
SHOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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