Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain.

The Journal of biological chemistry - 1 Jun 2001

Pitkänen J, Vähämurto P, Krohn K, Peterson P

Abstract excerpt

The autoimmune regulator (AIRE) gene, defective in the hereditary autoimmune disease APECED, encodes a transcriptional regulator protein. AIRE is expressed in the medullary epithelial cells and monocyte-dendritic cells of the thymus with lower expression in the spleen, fetal liver, and lymph nodes. At the cellular level, AIRE is located in microtubular structures of the cytoskeleton and in discrete nuclear dots...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIRE Protein
Share to Cytoskeleton
Share to Fatty Acids, Unsaturated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymph Nodes

Share to Microtubules

Share to Nuclear Localization Signals

Share to Thymus Gland

Share to U937 Cells

Source

Identifiers

PMID: 11274163
DOI: 10.1074/jbc.M008322200

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain.PMID 11274163Read ↗

Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targetingSemantic proximity Read ↗

AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers.Semantic proximity Read ↗

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouseSemantic proximity Read ↗

Localization of the APECED protein in distinct nuclear structuresSemantic proximity Read ↗

AireSemantic proximity Read ↗

Cloning of the APECED gene provides new insight into human autoimmunity.Semantic proximity Read ↗

Characterization of Regulatory Elements and Methylation Pattern of the Autoimmune Regulator (AIRE) PromoterSemantic proximity Read ↗

APECED-causing mutations in AIRE reveal the functional domains of the protein.Semantic proximity Read ↗

The autoimmune regulator: a key toward understanding the molecular pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.Semantic proximity Read ↗

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.Semantic proximity Read ↗

Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED).Semantic proximity Read ↗

Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.