Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.

Molecular and cellular biology - 1 Nov 2000

Spilianakis C, Papamatheakis J, Kretsovali A

Abstract excerpt

The class II transactivator (CIITA), the master regulator of the tissue-specific and interferon gamma-inducible expression of major histocompatibility complex class II genes, synergizes with the histone acetylase coactivator CBP to activate gene transcription. Here we demonstrate that in addition to CBP, PCAF binds to CIITA both in vivo and in vitro and enhances CIITA-dependent transcriptional activation of class...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Adenovirus E1A Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CREB-Binding Protein

Share to Exportin 1 Protein

Share to Genes, MHC Class II

Share to Histone Acetyltransferases

Share to Karyopherins

Share to Nuclear Localization Signals

Source

Open in PubMed Open full text

Identifiers

PMID: 11046145
DOI: 10.1128/MCB.20.22.8489-8498.2000
PMCID: PMC102155

Genes

CIITA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.PMID 11046145Read ↗

The histone acetyltransferase domains of CREB-binding protein (CBP) and p300/CBP-associated factor are not necessary for cooperativity with the class II transactivator.Semantic proximity Read ↗

Autoacetylation regulates P/CAF nuclear localization.Semantic proximity Read ↗

Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach.Semantic proximity Read ↗

Coordination of a transcriptional switch by HMGI(Y) acetylation.Semantic proximity Read ↗

GTP-dependent recruitment of CIITA to the class II major histocompatibility complex promoter.Semantic proximity Read ↗

Self-association of CIITA and its transactivation potential.Semantic proximity Read ↗

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.Semantic proximity Read ↗

PKCβΙΙ Augments NF-κB-Dependent Transcription at the CCL11 Promoter via p300/CBP-Associated Factor Recruitment and Histone H4 AcetylationSemantic proximity Read ↗

The AIR-1 encoded class II transactivator (CIITA): the master coordinator of MHC class II gene expression and .. more.Semantic proximity Read ↗

Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.Semantic proximity Read ↗

Acetylation of importin-alpha nuclear import factors by CBP/p300.Semantic proximity Read ↗

CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.