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Article

Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene.

Journal of neuroinflammation - 28 Feb 2007

Fendrick Sarah E, Xue Qing-Shan, Streit Wolfgang J

Abstract excerpt

BACKGROUND: Microglial neuroinflammation is thought to play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS). The purpose of this study was to provide a histopathological evaluation of the microglial neuroinflammatory response in a rodent model of ALS, the SOD1G93A transgenic rat...

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Source

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Identifiers

PMID: 17328801
DOI: 10.1186/1742-2094-4-9
PMCID: PMC1808448

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17328801-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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