Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders

26 May 2008

Abstract excerpt

KIT is a member of the tyrosine kinase family of growth factor receptors which is expressed on a variety of haematopoietic cells including mast cells. Stem cell factor (SCF)-dependent activation of KIT is critical for mast cell homeostasis and function. However, when KIT is inappropriately activated, accumulation of mast cells in tissues results in mastocytosis. Such dysregulated KIT activation is a manifestation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Disorders and Syndromes
Share to Mast cells and histamine
Share to Urticaria and Related Conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18500355
DOI: 10.1038/bjp.2008.204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disordersPMID 18500355Read ↗

Recent advances in the understanding of mastocytosis: the role of KIT mutations.Semantic proximity Read ↗

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms.Semantic proximity Read ↗

Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression.Semantic proximity Read ↗

Recent advances in the understanding and therapeutic management of mastocytosisSemantic proximity Read ↗

Tyrosine Kinase Inhibition in Mastocytosis: KIT and Beyond KIT.Semantic proximity Read ↗

Mastocytosis: from a Molecular Point of View.Semantic proximity Read ↗

Systemic Mastocytosis, KIT and the Effects of KIT Tyrosine Kinase Inhibitors on Mast Cell and Basophil Activation.Semantic proximity Read ↗

Tyrosine kinase inhibitors in the treatment of systemic mastocytosis.Semantic proximity Read ↗

Mastocytosis.Semantic proximity Read ↗

Molecular defects in mastocytosis: KIT and beyond KIT.Semantic proximity Read ↗

c-Kit and c-kit mutations in mastocytosis and other hematological diseasesSemantic proximity Read ↗

Update on diagnosis and treatment of mastocytosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.