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Article

KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance.

Oncogene - 27 Sept 2007

Zhu M-J, Ou W-B, Fletcher C D M, Cohen P S, Demetri G D, Fletcher J A

Abstract excerpt

Most gastrointestinal stromal tumors (GISTs) express oncogenic and constitutively active forms of the KIT or platelet-derived growth factor receptor alpha (PDGFRA) receptor tyrosine kinase proteins, and these kinase oncoproteins serve as targets for effective therapies. Given that mutant KIT oncoproteins serve crucial transforming roles in GISTs, we evaluated interactions with the KIT oncoproteins and determined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Kinase C-delta

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

Identifiers

PMID: 17452978
DOI: 10.1038/sj.onc.1210464

Genes

KIT
PDGFRA
CBL
EPHA4
GRB2
JAK1
PDGFRB
STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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