New Biochemical Insights into RIT GTPases Regulation and Membrane Interactions.

Abstract excerpt

Both RIT1 and RIT2 are members of the RAS superfamily of small GTPases, which regulate various cellular processes. RIT1 is widely expressed, whereas RIT2 is primarily found in neuronal tissues. Dysregulation of these proteins has been associated with several human diseases, including Noonan syndrome, cancer, Parkinson's disease, autism, and schizophrenia. Although RIT1 and RIT2 are often compared to classical RAS...

Topics

• Humans
• ras Proteins
• HEK293 Cells
• Cell Membrane
• Protein Binding
• Monomeric GTP-Binding Proteins