Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.

The EMBO journal - 2 Nov 1998

Timokhina I, Kissel H, Stella G, Besmer P

Abstract excerpt

The receptor tyrosine kinase Kit plays critical roles in hematopoiesis, gametogenesis and melanogenesis. In mast cells, Kit receptor activation mediates several cellular responses including cell proliferation and suppression of apoptosis induced by growth factor deprivation and gamma-irradiation. Kit receptor functions are mediated by kinase activation, receptor autophosphorylation and association with various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Enzyme Activation
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Mutation

Share to Phosphorylation

Share to Signal Transduction

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 9799234
DOI: 10.1093/emboj/17.21.6250
PMCID: PMC1170951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.PMID 9799234Read ↗

Lipid rafts are required for Kit survival and proliferation signals.Semantic proximity Read ↗

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms.Semantic proximity Read ↗

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.Semantic proximity Read ↗

Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.Semantic proximity Read ↗

c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.Semantic proximity Read ↗

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development.Semantic proximity Read ↗

The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.Semantic proximity Read ↗

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disordersSemantic proximity Read ↗

Normal and oncogenic forms of the receptor tyrosine kinase kit.Semantic proximity Read ↗

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells.Semantic proximity Read ↗

Combination therapy for KIT-mutant mast cells: targeting constitutive NFAT and KIT activity.Semantic proximity Read ↗

Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.