Article
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.
The EMBO journal - 2 Nov 1998
Timokhina I, Kissel H, Stella G, Besmer P
Abstract excerpt
The receptor tyrosine kinase Kit plays critical roles in hematopoiesis, gametogenesis and melanogenesis. In mast cells, Kit receptor activation mediates several cellular responses including cell proliferation and suppression of apoptosis induced by growth factor deprivation and gamma-irradiation....
Topics
- Animals
- Apoptosis
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Division
- Enzyme Activation
- GTP-Binding Proteins
- JNK Mitogen-Activated Protein Kinases
- Mast Cells
- Mice
- Mice, Inbred Strains
- Mitogen-Activated Protein Kinases
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphorylation