Article
Dissociation of halted T7 RNA polymerase elongation complexes proceeds via a forward-translocation mechanism.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2007
Zhou Yi, Navaroli Deanna M, Enuameh Metewo Selase, Martin Craig T
Abstract excerpt
A recent model for the mechanism of intrinsic transcription termination involves dissociation of the RNA from forward-translocated (hypertranslocated) states of the complex [Yarnell WS, Roberts JW (1999) Science, 284:611-615]. The current study demonstrates that halted elongation complexes of T7 RNA polymerase in the absence of termination signals can also dissociate via a forward-translocation mechanism....
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