Article
A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families.
European journal of human genetics : EJHG - 1 Sept 2007
Amundsen Silja Svanstrøm, Adamovic Svetlana, Hellqvist Asa, Nilsson Staffan, Gudjónsdóttir Audur H, Ascher Henry, Ek Johan, Larsson Kristina, Wahlström Jan, Lie Benedicte A, Sollid Ludvig M, Naluai Asa Torinsson
Abstract excerpt
Celiac disease (CD) is a gluten-induced enteropathy, which results from the interplay between environmental and genetic factors. There is a strong human leukocyte antigen (HLA) association with the disease, and HLA-DQ alleles represent a major genetic risk factor. In addition to HLA-DQ, non-HLA genes appear to be crucial for CD development. Chromosomal region 5q31-33 has demonstrated linkage with CD in several...
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