Article
Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32.
Tissue antigens - 1 Jan 2008
Adamovic S, Amundsen S S, Lie B A, Hellqvist A, Gudjónsdóttir A H, Ek J, Nilsson S, Wahlström J, Ascher H, Sollid L M, Naluai A T
Abstract excerpt
The previous genome-wide scan in Scandinavian families supported earlier evidence for linkage of a region on chromosome 5 (5q31-33) to coeliac disease. This study deals with further genetic mapping of an 18 cM region, spanning from marker GAh18A (131.87 Mb) to D5S640 (149.96 Mb). Linkage and association analyses were performed in a two-step approach. First, seven microsatellites were added. Strong evidence for...
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