Article
Genomewide linkage analysis of celiac disease in Finnish families.
American journal of human genetics - 1 Jan 2002
Liu Jianjun, Juo Suh-Hang, Holopainen Päivi, Terwilliger Joseph, Tong Xiaomei, Grunn Adina, Brito Miguel, Green Peter, Mustalahti Kirsi, Mäki Markku, Gilliam T Conrad, Partanen Jukka
Abstract excerpt
Celiac disease (CD), or gluten-sensitive enteropathy, is a common multifactorial disorder resulting from intolerance to cereal prolamins. The only established genetic susceptibility factor is HLA-DQ, which appears to explain only part of the overall genetic risk. We performed a genomewide scan of CD in 60 Finnish families. In addition to strong evidence for linkage to the HLA region at 6p21.3 (Z(max)>5),...
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