Article
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.
American journal of medical genetics. Part A - 1 Nov 2004
Rioux John D, Karinen Hannele, Kocher Kerry, McMahon Sheila Guschwan, Kärkkäinen Päivi, Janatuinen Esko, Heikkinen Markku, Julkunen Risto, Pihlajamäki Jussi, Naukkarinen Anita, Kosma Veli-Matti, Daly Mark J, Lander Eric S, Laakso Markku
Abstract excerpt
It has been reported that celiac disease (CD) is strongly associated with the HLA-DQ2 alleles DQA1*0501 and DQB1*0201. However, this association only accounts for a portion of the genetic component of CD. Several non-HLA loci and candidate genes that potentially contribute to CD susceptibility have been reported, but have not been confirmed. The aim of this study was to identify loci that contribute to disease...
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