Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies.

doi:10.1038/ng1706

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Article

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies.

Nature genetics - 1 Feb 2006

Skol Andrew D, Scott Laura J, Abecasis Gonçalo R, Boehnke Michael

Abstract excerpt

Genome-wide association is a promising approach to identify common genetic variants that predispose to human disease. Because of the high cost of genotyping hundreds of thousands of markers on thousands of subjects, genome-wide association studies often follow a staged design in which a proportion (pi(samples)) of the available samples are genotyped on a large number of markers in stage 1, and a proportion...

Topics

Alleles
Case-Control Studies
DNA Replication
Gene Frequency
Genetic Heterogeneity
Genetic Markers
Genetic Predisposition to Disease
Genetics, Medical
Genome, Human
Genotype
Humans

Source

Open in PubMed

Identifiers

PMID: 16415888
DOI: 10.1038/ng1706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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