Article
Optimal two-stage design for case-control association analysis incorporating genotyping errors.
Annals of human genetics - 1 May 2008
Zuo Y, Zou G, Wang J, Zhao H, Liang H
Abstract excerpt
Two-stage design is a cost effective approach for identifying disease genes in genetic studies and it has received much attention recently. In general, there are two types of two-stage designs that differ on the methods and samples used to measure allele frequencies in the first stage: (1) Individual genotyping is used in the first stage; (2) DNA pooling is used in the first stage. In this paper, we focus on the...
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