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Study designs for genome-wide association studies.

Advances in genetics - 1 Jan 2008

Kraft Peter, Cox David G

Abstract excerpt

Advances in high-throughput genotyping and a flood of data on human genetic variation from the Human Genome and HapMap projects have made genome-wide association studies technically feasible. However, researchers designing such studies face a number of challenges, including how to avoid subtle systematic biases and how to achieve sufficient statistical power to distinguish modest association signals from chance...

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PMID: 18358330
DOI: 10.1016/S0065-2660(07)00417-8

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