[Nucleophosmin mutations in hematological malignancies - review].

Abstract excerpt

Nucleophosmin (NPM) is a protein that shuttles between the nucleus, nucleoplasm and cytoplasm. NPM gene mutations and aberrant cytoplasmic NPM localization have been recently described in acute myelogenous leukemia (AML) with normal karyotype and in a few myelodysplastic syndromes. Expression of NPM mutant reduces the ability of Arf to initiate a p53 response and to induce cell cycle arrest. Clinical research has...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Nucleolus
• Share to fms-Like Tyrosine Kinase 3
• Share to Hematologic Neoplasms