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Article

Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia.

Biological psychiatry - 1 Jan 2008

Roffman Joshua L, Weiss Anthony P, Purcell Shaun, Caffalette Christopher A, Freudenreich Oliver, Henderson David C, Bottiglieri Teodoro, Wong Donna H, Halsted Charles H, Goff Donald C

Abstract excerpt

BACKGROUND: Folate deficiency may contribute to negative symptoms in schizophrenia, but the underlying mechanism remains uncertain. We examined whether the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C functional polymorphisms contribute to negative symptoms. METHODS: Outpatients with schizophrenia (n = 200) were evaluated with the Positive and Negative Syndrome Scale (PANSS). Subjects also...

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Source

Identifiers

PMID: 17543893
DOI: 10.1016/j.biopsych.2006.12.017

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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