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Article

Homocysteine, but not MTHFR gene polymorphism, influences depressive symptoms in patients with schizophrenia.

Journal of affective disorders - 1 Jul 2020

Zhang Yi, Zhao Junxiong, Wang Weiping, Fan Weixing, Tang Wei, Zhang Chen

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate metabolism in the process of one-carbon cycle and its deficiency results in elevated homocysteine concentration. In this study, we hypothesized that MTHFR C677T polymorphism and homocysteine concentration may play important roles in the development of depressive symptoms in schizophrenia. METHODS: We recruited 715 patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32379616
DOI: 10.1016/j.jad.2020.03.121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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